NOTAS A PIE DE PÁGINA:
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[2] Derendorf H., Nave R., Drollmann A., Cerasoli F., Wurst W. Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. European Respiratory Journal, 2006; 28:1042-1050. 

[3] Roller M., Zhang G., Troedson R.G., Leach C.L., Le Souëf P.N., Devadason S.G. Spacer inhaler technique and deposition  of extra fine aerosol in asthmatic children. European Respiratory Journal, 2007; 29:299-306. 

[4] Von Hollen D., Slater L., Hatley RHM. Impact of flow rate on NGI throat deposition from 3 HFA Inhaler formulations with anti-static valved holding chambers. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013; 26(2); A45-A46.

[5] Oliveira R.F., et al. VHC performance evaluation at constant flow: 30L/min. Proceedings of the ASME2015 International Mechanical Engineering Congress and Exposition, 2015 Houston Texas.

[6] Leach C., Colice G. A Pilot Study to Assess Lung Deposition of HFA-Beclomethasone and CFC-Beclomethasone from a pressurized Metered Dose Inhaler with and without add-on spacers and using varying breath hold times.  Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2010; 23(6):355-361.

[7] Dickens G., et al. Pharmacokinetics of flunisolide administered via metered dose inhaler with and without a spacer device and following oral administration. Annals of Allergy, Asthma & Immunology, 2000; Volume 84, 528-532. 

[8] Saunders K.B.  Misuse of inhaled bronchodilator agents.  Br Med J. 1965; 1:1037-1038. 

[9] Oprehek J., et al. Patient error in use of bronchodilator metered aerosols. Br Med J. 1976; 1:76.  

[10] Gardenhire D., Arzu A., Dean H., Myers T. A guide to aerosol delivery devices for respiratory therapists 3rd edition, American Association for Respiratory Care, 2013. 

[11] Nhlbi.nih.gov. Delivery devices in infants and young children. Consultado en septiembre del 2017. 

[12] Hsu W., et al. Evaluation of delivery efficiency from valved holding chambers with facemasks. Resp. Drug Delivery Europe, 2011; 2:505-510.  

[13] Lung.org. Managing asthma/Valved holding chambers. Consultado en septiembre del 2017. 

[14] Everard ML., Clark AR., Milner AD. Drug delivery from holding chamber with facemask. Arch Dis Child, 1992; 67:580-585.

[15] Mitchell J. et al. Electrostatic and inhaled medications: Influence on delivery via pressurized metered dose inhalers and add on devices. Respiratory Care, 2000. Volume 52(3):283-300.  

[16] Adaptado de: Hirst, PH., et al. Deposition and pharmacokinetics of an HFA formulation of Triamcinolone Acetonide delivered by pressurized metered dose inhaler. Journal of Aerosol Medicine. 2001; Volume 14 (2):155-166.  

[17] Adapted from Erzinger, S. et al. Facemaks and aerosol delivery in vivo.  Journal Aerosol Medicine  2007; 20 (Suppl 1):S78-S84

[18] Entre farmacias minoristas que afirman tener una marca preferida de espaciadores en sus farmacias. Se realizó una encuesta en línea con un total de 205 farmacéuticos de tiendas minoristas registrados.